✦ LIBER ✦

TCR-Vβ repertoire analysis with RT-PCR was useful for the early detection of pulmonary relapsed T-cell lymphoma after autologous peripheral blood stem cell transplantation

✍ Scribed by Hase, Hidenori; Tani, Kenzaburo; Nagayama, Hitomi; Watari, Kiyoshi; Takahashi, Satoshi; Ooi, Jun; Shirafuji, Naoki; Iseki, Tohru; Nakazaki, Yukoh; Yamashita, Takayuki; Nakamura, Tetsuya; Masunaga, Atsuko; Maekawa, Taira; Tojo, Arinobu; Asano, Shigetaka

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 147 KB
Volume: 64
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(200006)64:2<124::aid-ajh10>3.0.co;2-6

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✦ Synopsis

Pulmonary recurrence of malignant lymphoma is a rare event after stem cell transplantation. We report here a 45-year-old male who was successfully diagnosed with relapsed pulmonary T-cell lymphoma using an RT-PCR method. Clonal expansion of T cells expressing identical TCR V-D-J junction size (V␤5-J␤1.5) was demonstrated in lymphocyte groups obtained from both bronchoalveolar lavage fluid at relapse, and paraffin embedded lymph node samples resected when he was first diagnosed with angioimmunoblastic T-cell lymphoma. This method provided evidence to diagnose relapsed pulmonary angioimmunoblastic T-cell lymphoma in its early phase. Am.