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Long-term persistence of a nonintegrated lentiviral vector in mouse hematopoietic stem cells

โœ Scribed by Alexey V. Terskikh; Maxim A. Ershler; Nina J. Drize; Irina N. Nifontova; Joseph L. Chertkov


Book ID
113615971
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
519 KB
Volume
33
Category
Article
ISSN
0301-472X

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โœ Aaron C Logan; Carolyn Lutzko; Donald B Kohn ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 84 KB

Lentiviral vectors are more efficient at transducing quiescent hematopoietic stem cells than murine retroviral vectors. This characteristic is due to multiple karyophilic components of the lentiviral vector pre-integration complex. Lentiviral vectors are also able to carry more complex payloads than