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Long-term outcome of salvage high-dose chemotherapy in patients with germ cell tumor with poor prognostic features

✍ Scribed by Ugo De Giorgi; Giovanni Rosti; Roberto Salvioni; Giorgio Papiani; Michela Ballardini; Giorgio Pizzocaro; Maurizio Marangolo


Book ID
116956550
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
524 KB
Volume
29
Category
Article
ISSN
1078-1439

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## Abstract ## BACKGROUND High‐dose chemotherapy (HDCT) followed by hematopoietic stem cell support (HSCS) potentially may be curative in patients with germ cell tumor (GCT) who develop recurrent tumors or who have an inadequate response after receiving standard‐dose chemotherapy. The authors repo

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Forty-four patients with nonseminomatous germ cell tumors with "poor prognostic features" were entered on the VAB-5 regimen and 38 are evaluable. VAB-5 represents an intensified version of the VAB-4 protocol. Poor prognostic features were considered to be bulky metastases (>5 cm in diameter), palpab