High-dose chemotherapy with autologous stem cell support in poor-risk germ cell tumors
β Scribed by W. Siegert; O. Rick; J. Beyer
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 152 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0939-5555
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π SIMILAR VOLUMES
## Germ -cell tumors (GCTs) are very chemosensitive and highly curable cancers. For the small proportion of patients who fail conventional chemotherapy (CT), high-dose CT (HDCT) was introduced in France and elsewhere in 1982-1984. We report here on the French experience with HDCT in GCTs. At the C
## Abstract ## BACKGROUND. Highβdose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) has been reported to be effective in treating children with recurrent central nervous system (CNS) malignancies. ## METHODS. To evaluate the efficacy and toxicities of HDCT and ASCR, the medical reco
Forty-four patients with nonseminomatous germ cell tumors with "poor prognostic features" were entered on the VAB-5 regimen and 38 are evaluable. VAB-5 represents an intensified version of the VAB-4 protocol. Poor prognostic features were considered to be bulky metastases (>5 cm in diameter), palpab