Abstract
BACKGROUND.
Highโdose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) has been reported to be effective in treating children with recurrent central nervous system (CNS) malignancies.
METHODS.
To evaluate the efficacy and toxicities of HDCT and ASCR, the medical records of 27 children with recurrent CNS malignancies who received such therapy at St. Jude Children's Research Hospital between 1989 and 2004 were reviewed.
RESULTS.
The median age at diagnosis was 4.5 years (range, 0.4โ16.6 years) and that at ASCR was 6.7 years (range, 1.1โ18.5 years). Diagnoses included medulloblastoma (13 patients), primitive neuroectodermal tumor (3 patients), pineoblastoma (2 patients), atypical teratoid rhabdoid tumor (2 patients), ependymoma (3 patients), anaplastic astrocytoma (2 patients), and glioblastoma multiforme (2 patients). The 5โyear overall and progressionโfree survival (PFS) rates were 28.2% and 18.5%, respectively. The 5โyear PFS rate for patients aged <3 years at diagnosis (57.1%) was significantly better than older patients (5.0%) (P = .019). Among the 6 longโterm survivors (5 with M0 disease and 1 with M3 disease at diagnosis), 5 received both radiotherapy and HDCT as part of their salvage regimen; 4 were aged <3 years at diagnosis and had received chemotherapy only as part of frontline therapy. Two patients died of transplantโrelated toxicities; 44% experienced grade 3 or 4 transplantโrelated toxicities (toxicities were graded according to the National Cancer Institute Common Toxicity Criteria).
CONCLUSIONS.
HDCT with ASCR is not an effective salvage strategy for older children with recurrent CNS malignancies. The significantly better outcome in the younger cohort was most likely related to the use of radiotherapy as part of the salvage strategy. Cancer 2008. ยฉ 2008 American Cancer Society.