✦ LIBER ✦

Long-term neuroleptic treatment of chronic schizophrenic patients: Clinical and biochemical effects of withdrawal

✍ Scribed by K. J. Zander; B. Fischer; R. Zimmer; M. Ackenheil

Publisher: Springer
Year: 1981
Tongue: English
Weight: 578 KB
Volume: 73
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00431099

No coin nor oath required. For personal study only.

✦ Synopsis

In 17 chronic schizophrenic patients under chronic neuroleptic treatment for 13 years, a 30-day drug withdrawal resulted in early relapse of four patients, slight deterioration in five, and slight amelioration in eight patients. No incidence of neuroleptic symptoms such as tardive dyskinesia occurred. Prolactin in plasma and cerebrospinal fluid (CSF), not being elevated under chronic treatment, decreased significantly after 30 days of withdrawal. Homovanillic acid and 3-methoxy-4-hydroxyphenylglycol in CSF ranged normally and did not change during withdrawal. In contrast, plasma noradrenaline was elevated and decreased after drug discontinuation. No unequivocal relationship between biochemical and psychopathological features was found.

📜 SIMILAR VOLUMES

Neuroendocrine effects of clonidine in c

Neuroendocrine effects of clonidine in chronic schizophrenic patients under long-term neuroleptic therapy and after drug withdrawal: Relations to psychopathology

✍ F. Müller-Spahn; M. Ackenheil; M. Albus; C. Botschev; D. Naber; D. Welter 📂 Article 📅 1986 🏛 Springer 🌐 English ⚖ 642 KB

Neuroendocrine effects of apomorphine in

Neuroendocrine effects of apomorphine in chronic schizophrenic patients under long-term neuroleptic therapy and after drug withdrawal: Relations to psychopathology and tardive dyskinesia

✍ F. Müller-Spahn; M. Ackenheil; M. Albus; G. May; D. Naber; D. Welter; K. Zander 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 588 KB

Effect of adjuvant reserpine treatment o

Effect of adjuvant reserpine treatment on catecholamine metabolism in schizophrenic patients under long-term neuroleptic treatment

✍ G. Bagdy; G. Perenyi; E. Frecska; A. Seregi; M. I. K. Fekete; L. Tothfalusi; K. 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 434 KB

The effects of long-term benzodiazepine

The effects of long-term benzodiazepine treatment and graded withdrawal on psychometric performance

✍ Martyn S. Sakol; Kevin G. Power 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 420 KB

Twelve patients were assessed prior to and during 4 weeks' graded withdrawal from long-term benzodiazepine treatment. A control group of ten healthy drug-free individuals were assessed over the same period. Psychometric measures included Four Choice Reaction Time--Decision (FCRT-D), Four Choice Reac

Virological and biochemical long-term fo

Virological and biochemical long-term follow-up of patients with chronic hepatitis c treated with interferon

✍ Inmaculada Castillo; Javier Bartolomé; Sonia Navas; Sara Gonzalez; Montserrat He 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 557 KB

We studied the long-term outcomes of 43 patients with chronic hepatitis C treated with one or two interferon cycles, in relation to hepatitis C virus RNA in serum and peripheral-blood mononuclear cells. After the first interferon cycle, 15 (35%) patients had normal transaminase levels, although only

Effects of abrupt and gradual withdrawal

Effects of abrupt and gradual withdrawal from long-term haloperidol treatment on open field behavior of rats

✍ M. M. Bernardi; J. Palermo Neto 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 326 KB

The effects of abrupt and gradual withdrawal from long-term haloperidol treatment on rat open field behavior was studied. Abrupt withdrawal induced a significant increase in all parameters of activity observed except defecation, this increase being higher 72 h after the last haloperidol injection. R