Effects of abrupt and gradual withdrawal from long-term haloperidol treatment on open field behavior of rats

✍ Scribed by M. M. Bernardi; J. Palermo Neto

• Publisher: Springer
• Year: 1979
• Tongue: English
• Weight: 326 KB
• Volume: 65
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00492211

✦ Synopsis

The effects of abrupt and gradual withdrawal from long-term haloperidol treatment on rat open field behavior was studied. Abrupt withdrawal induced a significant increase in all parameters of activity observed except defecation, this increase being higher 72 h after the last haloperidol injection. Results were considered to be a consequence of supersensitivity of central dopaminergic receptors. These differences were almost unobservable in animals gradually withdrawn, thus suggesting that the phenomenon is reversible.