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Long-Term Follow-Up of Stage III Testicular Carcinoma Treated With Mithramycin (Plicamycin)

✍ Scribed by Kennedy, B. J. ;Torkelson, Jane L.

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
212 KB
Volume
24
Category
Article
ISSN
0098-1532

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✦ Synopsis

In 1965 we reported mithramycin (plicamycin) to produce objective regression in 7 of 12 patients with advanced testicular carcinoma. Between 1963 and 1975 mithramycin was administered to 62 patients with advanced testicular carcinoma as the initial 1 chemotherapy and to 30 patients who failed 1 to respond to prior chemotherapies. There were 13 complete regressions (23%) in 56 ' patients who as initial chemotherapy received more than one course of mithramy-cin. The median follow-up is 23 years with 10 patients still alive. A partial regression occurred in 11 (18%), all of whom are dead. Of 30 patients receiving mithramycin after prior chemotherapies, none had a complete regression, 5 had a partial regression, and all are dead. Of 13 patients undergoing complete regression, 85% never had a recurrence of testicular carcinoma. The median follow-up of 23 years implies that these patients are cured.

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