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Long-term follow-up of Lambert-Eaton syndrome treated with intravenous immunoglobulin

โœ Scribed by Salomon Muchnik; Adriana S. Losavio; Alfredo Vidal; Leila Cura; Claudio Mazia

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
194 KB
Volume
20
Category
Article
ISSN
0148-639X

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โœฆ Synopsis

Recent reports have shown that patients with Lambert-Eaton myasthenic syndrome (LEMS) improve transiently after high-dose intravenous immunoglobulin (IVIG) administration. Information about the usefulness of IVIG for long-term treatment is rather scanty. Our findings demonstrate the efficacy of monthly IVIG courses at a dose of 0.4 g/kg/day for 5 days, in a 41-year-old patient with LEMS without detectable malignancy. Improvement in limb strength, peak expiratory flow rate, and electrophysiological parameters, as well as clinical signs following IVIG, was evident as early as 7 days after the first course and is still maintained at 24-months follow-up.

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