The natural history of PRV is characterized by a prolonged period of myeloproliferation chiefly affecting the red cell series. It can be controlled by venesection and cytotoxic agents. In this case report the patient declined further 'standard' chemotherapy to control his disease and the use of rela
Long-term effects of the treatment of polycythemia vera with recombinant interferon-α
✍ Scribed by Richard T. Silver
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 143 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0008-543X
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Following reports that recombinant interferon alfa (rlFNu), besides inducing clinical and hematologic remission in polycythemia Vera (PV), can also resolve intractable pruritus, we used rlFNu to treat 13 PV patients complaining of severe pruritus refractory to conventional treatment (venesection and
We studied the effects of recombinant interferon alpha-2a (IFN-alpha) in 36 patients with polycythemia Vera (PV) previously treated with phlebotomy and/or conventional cytostatic agents. In each patient, after at least 2 months of discontinuation of any cytotoxic therapy, the hematocrit (Hmt) was fi
We periodically analyzed bone-marrow cytogenetic features in 8 patients belonging to a series of 38 subjects with polycythemia vera (PV), all treated with recombinant interferonalpha 2a (rIFN-alpha) at a weekly dose of 9,000,000 IU. Six out of these 8 patients never showed any chromosome alterations
## BACKGROUND. Recombinant interferon-␣-2b (rIFN-␣-2b) has shown therapeutic potential in patients with chronic myelogenous leukemia and other myeloproliferative disorders (MPDs), including the ability to suppress the abnormal hematopoietic clone and to reverse myelofibrosis. This study was conduc