Polycythemia vera treated with recombinant interferon-alpha 2a: Evidence of a selective effect on the malignant clone

✍ Scribed by Massaro, Paolo; Foa, Paolo; Pomati, Mauro; LaTargia, Maria Luisa; Iurlo, Alessandra; Clerici, Claudia; Caldiera, Sarah; Fornier, Monica; Maiolo, Anna Teresa

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 15 KB
• Volume: 56
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/(sici)1096-8652(199710)56:2<126::aid-ajh10>3.0.co;2-a

✦ Synopsis

We periodically analyzed bone-marrow cytogenetic features in 8 patients belonging to a series of 38 subjects with polycythemia vera (PV), all treated with recombinant interferonalpha 2a (rIFN-alpha) at a weekly dose of 9,000,000 IU. Six out of these 8 patients never showed any chromosome alterations, while 2 displayed at diagnosis the presence of trisomy 8 in all bone-marrow metaphases. Interestingly enough, in these 2 patients rIFNalpha treatment was able to induce not only complete hematological response but also the disappearance of trisomy 8, as shown by conventional cytogenetic investigation and fluorescence in situ hybridization performed on bone-marrow cells after 1 year of treatment. This finding indicates that, as previously shown in chronic myeloid leukemia, in PV rIFN-alpha can also eradicate the malignant clone by means of a selective effect on bone-marrow transformed cells. Am.