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Long-term effect of unilateral pallidotomy on levodopa-induced dyskinesia

✍ Scribed by Galit Kleiner-Fisman; Andres Lozano; Elena Moro; Yu-Yan Poon; Anthony E. Lang

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
401 KB
Volume
25
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Unilateral pallidotomy has been effectively used to treat parkinsonism and reduce levodopa induced dyskinesia (LID). We sought to determine the long‐term effects of pallidotomy on LID in 10 patients who had initial benefit from pallidotomy but went on to require DBS surgery for symptom progression. The Dyskinesia Rating Scale (DRS) was used to rate and quantify LID in a blinded fashion. Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID. Β© 2010 Movement Disorder Society

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