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Long-term administration of toxic doses of paracetamol (acetaminophen) to rats

✍ Scribed by Henrik E. Poulsen; Per Thomsen

Book ID
114796594
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
708 KB
Volume
8
Category
Article
ISSN
0106-9543

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Toxic Doses of Acetaminophen Suppress He
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✍ Bernhard H. Lauterburg; Jerry R. Mitchell πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 563 KB

The effect of a toxic dose of acetaminophen on hepatic glutathione turnover was studied in fed and fasted rats. Following the administration of 1 g m per kg of acetaminophen, the fractional rate of glutathione turnover increased from 0.19 to 0.28 hr-' in fed rats and from 0.43 to 0.50 hr-' in rats f