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Behavioural Subsensitivity Induced by Long-term Administration of a Low Dose of Haloperidol to Rats

✍ Scribed by ROBERTO FRUSSA-FILHO; VANESSA COSTHEK ABÍLIO; MARCELO BERGAMO; JOãO PALERMO-NETO

Book ID
118110673
Publisher
Pharmaceutical Press
Year
1997
Tongue
English
Weight
447 KB
Volume
49
Category
Article
ISSN
2042-7158

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✍ Robert Lalonde; M. I. Botez 📂 Article 📅 1985 🏛 Springer 🌐 English ⚖ 440 KB

Male albino rats were injected with 25 mg/kg of phenytoin (PHT) every day for 20 consecutive days and were tested on days 21 and 28 for their response to 1 or 2 mg/kg of muscimol, a GABA receptor agonist. Rats treated with PHT showed a decreased responsiveness to muscimol-induced catalepsy (2 mg/kg)