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Long-lasting antinociceptive effect of RC-160, a somatostatin analog, in mice and rats

✍ Scribed by Alain Eschalier; Olivier Aumaître; Denis Ardid; Joseph Fialip; Pierre Duchêne-Marullaz


Book ID
115887130
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
331 KB
Volume
199
Category
Article
ISSN
0014-2999

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We investigated the effects of the potent somatostatin analog RC-160 on the growth of human osteosarcoma cell lines SK-ES-I and MNNG/HOS, transplanted into nude mice or cultured in vitro. Growth of SK-ES-I and MNNG/HOS tumors in nude mice was significantly inhibited after 4 weeks of treatment with d

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## Abstract Nude mice bearing xenografts of the androgen‐independent human prostate‐cancer cell line PC‐3 were treated for 4 weeks with somatostatin analog RC‐160, bombesin/gastrin‐releasing peptide (GRP) antagonist (RC‐3095), or the combination of both peptides. In the first experiment, treatment