Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice

✍ Scribed by Jacek Pinski; Andrew V. Schally; Gabor Halmos; Karoly Szepeshazi; Kate Groot

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 627 KB
• Volume: 65
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19960315)65:6<870::aid-ijc27>3.0.co;2-6

✦ Synopsis

We investigated the effects of the potent somatostatin analog RC-160 on the growth of human osteosarcoma cell lines SK-ES-I and MNNG/HOS, transplanted into nude mice or cultured in vitro. Growth of SK-ES-I and MNNG/HOS tumors in nude mice was significantly inhibited after 4 weeks of treatment with daily S.C. injections of 100 pg RC-160, as measured by a reduction in tumor volume and weight. Histologically, the number of mitotic cells was decreased in the groups treated with RC-160. In mice bearing either tumor model, administration of RC-I60 significantly decreased serum growth hormone and insulin-like growth factor I (IGF-I) levels. Specific highaffinity receptors for somatostatin and epidermal growth factor were found on membranes of MNNG/HOS tumors but not on SK-ES-I tumors. Receptor analyses also demonstrated highaffinity binding sites for ICF-I on membranes of both tumors. In cell cultures, the proliferation rate of MNNG/HOS cells, but not of SK-ES-I, was significantly suppressed by RC-160. Our findings demonstrate that RC-I60 can significantly inhibit the growth of SK-ES-I and MNNG/HOS osteosarcomas in mice.