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Lonazolac analogues: molecular modeling, synthesis, and in vivo anti-inflammatory activity

✍ Scribed by Mohamed A. H. Ismail; Jochen Lehmann; Dalal A. Abou El Ella; Amgad Albohy; Khaled A. M. Abouzid

Book ID
105770931
Publisher
Springer-Verlag
Year
2009
Tongue
English
Weight
482 KB
Volume
18
Category
Article
ISSN
1054-2523

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## Abstract A variety of __N__‐aryl‐7‐cyano‐2,3‐dihydro‐1__H__‐pyrrolizine‐5‐carboxamides **5**, **6**, **8**, and **9** were synthesized __via__ reaction of the 2‐amino derivatives **4** with acid chlorides and aromatic aldehydes. Meanwhile, **4a**,**b** were obtained through the reaction of 2‐pyr