LOHAS: loss-of-heterozygosity analysis suite
β Scribed by Hsin-Chou Yang; Lun-Ching Chang; Richard M. Huggins; Chun-Houh Chen; Charles G. Mullighan
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 653 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The Knudson "two-hit" hypothesis has provided the rationale for studies that aim to identify tumor-suppressor genes by mapping regions of allelic loss (loss of heterozygosity, LOH). Although LOH has been found in practically all types of tumors, very few such projects have been successful in identif
## Abstract Because allelotype analysis of tumors has been important in the identification of new tumor suppressor genes, here we studied loss of heterozygosity (LOH) in a wellβdefined animal experimental system. We analyzed spontaneous liver tumors from C3HHc Γ C57BL/61 (B6C3F1) mice and urethaneβ
I n this issue of Cancer Cytopathology, Abati et al. 1 , using the cellular material in fine-needle aspiration (FNA) biopsies, demonstrate the feasibility of detecting loss of heterozygosity (LOH) at the p53 locus on chromosome 17, the putative neuroblastoma tumor suppressor locus on chromosome 1, a
Reprints are not available.