Locating the rate-determining step(s) for three-step hydrolase-catalyzed reactions with dynafit

The “dimer nucleophile mechanism” for re

The “dimer nucleophile mechanism” for reactions with rate-determining first step: Derivation of the whole kinetic law and further treatment of kinetic results

✍ Cecilia E. Silvana Alvaro; Norma Sbarbati Nudelman 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB

Overwhelming evidence has been previously reported for the existence of the so-called "dimer nucleophile mechanism" in aromatic nucleophilic substitutions by amines in aprotic solvents, for which the most prominent feature is the fourth-order kinetics (third order in amine) that has been observed wi