The “dimer nucleophile mechanism” for reactions with rate-determining first step: Derivation of the whole kinetic law and further treatment of kinetic results
✍ Scribed by Cecilia E. Silvana Alvaro; Norma Sbarbati Nudelman
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 125 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0538-8066
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✦ Synopsis
Overwhelming evidence has been previously reported for the existence of the so-called "dimer nucleophile mechanism" in aromatic nucleophilic substitutions by amines in aprotic solvents, for which the most prominent feature is the fourth-order kinetics (third order in amine) that has been observed with many different substrate-nucleophile systems, especially those in which departure of the nucleofuge is the rate-determining step. The mechanism has been confirmed by several other features, although other alternative mechanisms were suggested to explain the fourth-order kinetics, no one has been able to explain the other above-mentioned features.