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Localized 1H NMR spectroscopy in Canavan's Disease: A report of two cases

✍ Scribed by S. J. Austin; A. Connelly; D. G. Gadian; J. S. Benton; E. M. Brett

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
400 KB
Volume
19
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Two children with Canavan's Disease, an autosomal recessive leukodystrophy, were studied by localized ^1^H spectroscopy. The N‐acetylaspartate (NAA) signal intensity was high relative to other metabolite signals, and the signal intensity from choline‐containing compounds was low. These findings are discussed in relation to a possible role for NAA in normal myelination. Β© 1991 Academic Press, Inc.

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