𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Localization of two X-linked mental retardation (XLMR) genes to Xp: MRX37 gene at Xp22.31-p22.32 and a putative MRX gene on Xp22.11-p22.2

✍ Scribed by Bar-David, Shirly ;Lerer, Israela ;Sarfaty, Chava Kimchi ;Kohan, Zully Gelman ;Meiner, Vardiella ;Zlotogora, Joel ;Abeliovich, Dvorah

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
527 KB
Volume
64
Category
Article
ISSN
0148-7299

No coin nor oath required. For personal study only.

✦ Synopsis

MRX genes of 2 families with X-linked mental retardation (XLMR) were localized by linkage analysis. In family A, the gene was mapped to Xp22.31-p22.32, with significant LOD scores to various Xp22 markers within a distance of 6 Mb between DXS1223 and DXS1224. The MRX gene of this family was designated MRX37. In a mentally retarded female who is a carrier of the MRX37 gene, a random pattern of X inactivation was demonstrated. In family B, a positive LOD score, although not significant (<+2), was found with the marker DXS1202 at Xp22.11-p22.2.

πŸ“œ SIMILAR VOLUMES

Regional localization of two genes for n
Regional localization of two genes for nonspecific X-linked mental retardation to Xp22.3–p22.2 (MRX49) and Xp11.3–p11.21 (MRX50)
✍ Claes, S.; Vogels, A.; Holvoet, M.; Devriendt, K.; Raeymaekers, P.; Cassiman, J. πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 63 KB πŸ‘ 2 views

Two families with nonspecific X-linked mental retardation (XLMR) are presented. In the first family, MRX49, 5 male patients in 2 generations showed mild to moderate mental retardation. Two-point linkage analysis with 28 polymorphic markers, dispersed over the X-chromosome, yielded a maximal LOD scor

Regional localization of an X-linked men
Regional localization of an X-linked mental retardation gene to Xp21.1-Xp22.13 (MRX38)
✍ Schutz, Christopher K.; Ives, Elizabeth J.; Chalifoux, Maryse; MacLaren, Linda; πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 694 KB

A gene responsible for X-linked mental retardation with macrocephaly and seizures (MRX38) in a family with five affected males in three generations was localized to Xp21.1-p22.13 by linkage analysis. Recombination events placed the gene between DXS1226 distally and DXS1238 proximally, defining an in

Regional localization of a nonspecific X
Regional localization of a nonspecific X-linked mental retardation gene (MRX59) to Xp21.2-p22.2
✍ Carpenter, Nancy J.; Brown, W. Ted; Qu, Yong; Keenan, Kathy L. πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 54 KB πŸ‘ 2 views

## Linkage analysis was performed on a fourgeneration family with nonspecific mental retardation (MRX59 ). The five affected males, ranging in age from 2 years to 52 years, have a normal facial appearance and mild to severe mental impairment. Four obligate carriers are physically normal and not ret