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Localization of the nucleolar organizer by computer-aided analysis of a variant no. 21 in a human isolate

✍ Scribed by Alice O. Martin; L. Miller; J. L. Simpson; C. Thomas; M. S. Rzeszotarski; S. Elias; Gloria E. Sarto; V. A. Patel

Publisher: Springer
Year: 1979
Tongue: English
Weight: 699 KB
Volume: 48
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00286906

No coin nor oath required. For personal study only.

✦ Synopsis

A variant chromosome no. 21 consisting of two stalks and two satellites in tandem was detected during a survey of a human isolate. The variant segregated in three generations of a large kindred. One male had the variant no. 21, a metacentric Y, and a 47,XXY complement; however, no other evidence of chromosomal nondisjunction was found. Computer-aided analysis of sequentially stained variant no. 21 chromosomes indicated that silver-stained material corresponded to the proximal stalk region (as defined by Giemsa), but often covered both the distal stalk and satellite (also as defined by Giemsa). These data support the hypothesis that human nucleolar organizers are localized to the stalks of acrocentric chromosomes.

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