Localization of radiolabeled monoclonal anti-CEA antibodies and fragments in colon carcinoma: Diagnostic and therapeutic approach
β Scribed by Mach, Jean-Pierre; Buchegger, F.; Grob, J.-Ph.; Volant, J.-C.; Curchod, S.; Johner, B.; Pettavel, J.; von Fliedner, V.; Bischof-Delaloye, A.; Delaloye, B.
- Book ID
- 122594766
- Publisher
- Elsevier Science
- Year
- 1986
- Weight
- 86 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0883-2897
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## Abstract Three different monoclonal antibodies (mabs) directed against conformationβdependent protein determinants in carcinoembryonic antigen (CEA) were evaluated for tumorimmunolocalization of CEAβcontaining human tumors grown in nude mice. The antibodies were of high affinity and of the IgG~1
The rate of catabolism of a radiolabelled monoclonal anti-CEA antibody has been compared with that of control IgG1 in control nude mice and in mice with CEA producing xenografts and antigen negative xenografts. The rate of catabolism of antibody, but not of IgG, was increased 3-4 fold in mice with x