Radioimmunotherapy in humans is limited by toxicity to normal tissues, caused by circulating radio-antibody. Second antibody directed against the first (anti-tumor) antibody accelerates clearance of first antibody from normal tissues, and may thus improve the therapeutic ratio. The effect of second
Localization of intraperitoneal xenografts of human colon cancer by radiolabeled anti-CEA antibodies
β Scribed by Rosemary B. Duda; Jeffrey Y. C. Wong; Raymond J. Paxton; Barbara G. Beatty; Lawrence E. Williams; John E. Shively; J. David Beatty
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 541 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The biodistribution and pharmacokinetics of 2 monoclonal antibodies (MAbs) specific for ovarian carcinoma, O C I25 and OV-TL3, were studied in nude mice bearing intraperitoneally (i.p.) growing human ovarian carcinoma xenografts of NIH:OVCAR-3. The ovarian carcinoma xenografts grew as non-adherent c
The relationship between tumour size and the uptake of three radiolabelled anti-CEA localising antibodies (A5B7, 1H12 and PK2G) into a human colon tumour xenograft (MaWi) has been examined. For tumour weights greater than 100 mg (109-873 mg) there was a strong positive correlation between absolute u
The rate of catabolism of a radiolabelled monoclonal anti-CEA antibody has been compared with that of control IgG1 in control nude mice and in mice with CEA producing xenografts and antigen negative xenografts. The rate of catabolism of antibody, but not of IgG, was increased 3-4 fold in mice with x
## Abstract Three different monoclonal antibodies (mabs) directed against conformationβdependent protein determinants in carcinoembryonic antigen (CEA) were evaluated for tumorimmunolocalization of CEAβcontaining human tumors grown in nude mice. The antibodies were of high affinity and of the IgG~1