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The effect of second antibody clearance on the distribution and dosimetry of radiolabelled anti-cea antibody in a human colonic tumor xenograft model

✍ Scribed by R. Barbara Pedley; Roger Dale; Joan A. Boden; Richard H. J. Begent; Pat A. Keep; Alan J. Green

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
651 KB
Volume
43
Category
Article
ISSN
0020-7136

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✦ Synopsis

Radioimmunotherapy in humans is limited by toxicity to normal tissues, caused by circulating radio-antibody. Second antibody directed against the first (anti-tumor) antibody accelerates clearance of first antibody from normal tissues, and may thus improve the therapeutic ratio. The effect of second antibody both on anti-tumor antibody distribution and on tumor and normal tissue radiation doses, has been investigated in nude mice bearing colonic tumor xenografts. Second antibody, gfven either 6 or 24 hr after the first, rapidly cleared circulating activity and reduced the calculated radiation dose to all tissues except the spleen, where it rose by I I and 43% 7 I %, while that to the tumor was reduced by 8 I d a n d 58%,

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