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Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2

✍ Scribed by M. Ala-Kapee; H. Nevanlinna; M. Mali; M. Jalkanen; J. Schröder


Book ID
112501281
Publisher
Springer
Year
1990
Tongue
English
Weight
460 KB
Volume
16
Category
Article
ISSN
1572-9931

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The protein designated as insulin receptor substrate-1 (IRS-1) is a major substrate for the insulin receptor tyrosine kinase. Since post-receptor defects in the insulin signalling pathway are a common feature of Type 2 (noninsulin-dependent) diabetes mellitus, we have cloned the human IRS-1 gene in