Breast cancer resistance protein (BCRP) is an efflux transporter that plays an important role in drug disposition. The goal of this study was to investigate the interactions of azole antifungal agents, ketoconazole, itraconazole, fluconazole, and voriconazole, with BCRP. First, the effect of the azo
β¦ LIBER β¦
Localization of Breast Cancer Resistance Protein (BCRP) in Microvessel Endothelium of Human Control and Epileptic Brain
β Scribed by Eleonora Aronica; Jan A. Gorter; Sandra Redeker; Erwin A. Van Vliet; Marja Ramkema; George L. Scheffer; Rik J. Scheper; Paul Van Der Valk; Sieger Leenstra; Johannes C. Baayen; Wim G. M. Spliet; Dirk Troost
- Book ID
- 109108767
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2005
- Tongue
- English
- Weight
- 388 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0013-9580
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## Abstract Breast cancer resistance protein (BCRP) is a member of ATPβbinding cassette transporters that has an Nβterminal ATP binding domain and a Cβterminal transmembrane domain (TM). Expression of wildβtype BCRP confers resistance to multiple chemotherapeutic agents such as mitoxantrone, SNβ38
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