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Role of Cys-603 in dimer/oligomer formation of the breast cancer resistance protein BCRP/ABCG2

✍ Scribed by Kumie Kage; Toshiro Fujita; Yoshikazu Sugimoto

Book ID: 108583567
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 367 KB
Volume: 96
Category: Article
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2005.00126.x

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## Abstract Breast cancer resistance protein (BCRP) is a member of ATP‐binding cassette transporters that has an N‐terminal ATP binding domain and a C‐terminal transmembrane domain (TM). Expression of wild‐type BCRP confers resistance to multiple chemotherapeutic agents such as mitoxantrone, SN‐38