Localisation of the Gγ-, Aγ-, δ- and β-globin genes on the short arm of human chromosome 11
✍ Scribed by Jeffreys, Alec J.; Craig, Ian W.; Francke, Uta
- Book ID
- 109716427
- Publisher
- Nature Publishing Group
- Year
- 1979
- Tongue
- English
- Weight
- 385 KB
- Volume
- 281
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/281606a0
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📜 SIMILAR VOLUMES
Southern blotting and DNA sequencing after polymerase chain reaction (PCR) amplification provide evidence for the frequent occurrence (in 7 out of 24 chromosomes) of a short conversion G gamma----A gamma in the 3' end of the human fetal A gamma globin gene. This short conversion is characterized by
An investigation of the correlation between the y->p-globin switch and DNA methylation was carried out. The restriction patterns obtained with methylation-sensitive and -insensitive enzymes indicated hypomethylation in the promoter region of the r-globin genes in fetal liver DNA but high methylation