Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both bone formation and bone density. A bone chamber study in rats
✍ Scribed by Ola Belfrage; Uldis Kesteris; Magnus Tägil
- Book ID
- 116320438
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 60 KB
- Volume
- 42
- Category
- Article
- ISSN
- 8756-3282
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To study the anti-resorptive effects of zoledronate and pamidronate on growing long bones we have performed a histomorphometric analysis of the three regions of the proximal tibial cancellous bone of bone formed before, during, and after drug treatment. Male rats (190-220 g) were treated subcutaneou
## Abstract Remodeling of a bone graft can be influenced both by anabolic substances, such as a bone morphogenic protein (BMP) and by anticatabolic substances, such as the bisphosphonates. BMPs are potent bone anabolic substances, but also boost catabolism and cause resorption. Bisphosphonates inhi