Predisposing germline mutations in the BRCAl gene were identified recently in families with 17qlinked breast and ovarian cancers. Using single-strand conformation polymorphism (SSCP) analysis, we examined primary breast cancers for mutations in coding exons of BRCAl in a panel of 103 patients, of wh
LKB1 gene mutations in Japanese lung cancer patients
โ Scribed by Ryoichi Onozato; Takayuki Kosaka; Hiroyuki Achiwa; Hiroyuki Kuwano; Takashi Takahashi; Yasushi Yatabe; Tetsuya Mitsudomi
- Book ID
- 108583991
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 116 KB
- Volume
- 98
- Category
- Article
- ISSN
- 1347-9032
No coin nor oath required. For personal study only.
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## Abstract Much evidence has accumulated that the epidermal growth factor receptor (__EGFR__) and its family members are strongly implicated in the development and progression of lung cancers. Somatic mutations of the __EGFR__ gene were found in about 25โ40% of Japanese lung cancer patients. More