Living with and without the maintenance cytosine methyltransferase, Dnmt1
โ Scribed by Richard Meehan
- Book ID
- 119380903
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 45 KB
- Volume
- 189
- Category
- Article
- ISSN
- 0378-4274
No coin nor oath required. For personal study only.
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## Abstract In mammals Dnmt1 is the DNA methyltransferase chiefly responsible for maintaining genomic methylation patterns through DNA replication cycles, but how its maintenance activity is controlled is still not well understood. Interestingly, Uhrf1, a crucial cofactor for maintenance of DNA met
## Abstract Alteration of DNA methylation is one of the most consistent epigenetic changes in human cancers. DNA methyltransferase (DNMT) 1 is a major enzyme involved in establishing genomic methylation patterns. Most of the studies concerning DNMT1 expression in human cancers have been performed o