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Living Polymerization of α-Amino Acid N-Carboxyanhydrides (NCA) upon Decreasing the Reaction Temperature

✍ Scribed by Willy Vayaboury; Olivia Giani; Hervé Cottet; André Deratani; François Schué

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
93 KB
Volume
25
Category
Article
ISSN
1022-1336

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✦ Synopsis

Abstract

Summary: The n‐hexylamine‐initiated polymerization of N~ε~‐trifluoroacetyl‐L‐lysine N‐carboxyanhydride in N,N‐dimethyformamide was studied by nonaqueous capillary electrophoresis. A polypeptide with a broad molecular weight distribution was obtained and side reactions were clearly identified for polymerization at room temperature. The possibility of living polymerization at 0 °C was demonstrated.

Synthesis of living polypeptides by primary amine initiated polymerization of NCA at low temperatures.

imageSynthesis of living polypeptides by primary amine initiated polymerization of NCA at low temperatures.

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