✦ LIBER ✦

Liver Transplantation in a Patient with Pulmonary Hypertension at High Altitude

✍ Scribed by Kefeng Dou; Desheng Wang; Qingchuan Zhao; Zhenshun Song; Shuqiang Yue; Kaishan Tao; Shaoyang Chen; Yong He; Zhenyu Ti

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 121 KB
Volume: 21
Category: Article
ISSN: 1080-6032
DOI: 10.1016/j.wem.2009.12.006

No coin nor oath required. For personal study only.

✦ Synopsis

Chronic hypoxia at high altitude stresses many of the body's homeostatic mechanisms. As a consequence, the body develops alveolar hypoxia, hypoxemia, and polycythemia, which in turn causes vasoconstriction, pulmonary hypertension, and an increased risk of atherothrombotic complications. We report a successful liver transplantation in a patient with pulmonary hypertension who lives 4500 m above sea level. Pulmonary hypertension and hypercoagulable state induced by chronic hypoxia at high altitude may increase the risk of cardiopulmonary complication and perioperative mortality. The patient was discharged in good condition with normal liver function at the 34th postoperative day. After 41 months of follow-up, the patient is alive and well with a continued normalization of hepatic function and is continuing to live at 4500 m above sea level.

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