✦ LIBER ✦

Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression

✍ Scribed by P. J. Cowen; S. L. McCance; P. R. Cohen; D. L. Julier

Book ID: 104776172
Publisher: Springer
Year: 1989
Tongue: English
Weight: 255 KB
Volume: 99
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00442813

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✦ Synopsis

The addition of lithium to the tricyclic antidepressant medication of 11 depressed patients resulted in an increase in the prolactin response to L-tryptophan after both 4 days and 4 weeks of lithium treatment. There was also a significant fall in Hamilton Depression scores. The results suggest that lithium and tricyclic antidepressants may act synergistically to enhance certain aspects of brain 5-HT function in depressed patients.

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