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Lithium enediolates and dienediolates of carboxylic acids in synthesis: Alkylation with secondary halides

✍ Scribed by Eva M. Brun; Salvador Gil; Ramón Mestres; Margarita Parra

Book ID
104208964
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
947 KB
Volume
54
Category
Article
ISSN
0040-4020

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✦ Synopsis

High yields in the alkylation of dianions of ex,l~-unsaturated carboxylic acids with secondary halides can be obtained despite elimination reactions occurring, cx-Regioseleetivity for the alkylation of but-2-enoic acids (1-4) is seldom obtained. Although double bond stereoselectivity is higher than 99% for ?-alkylated products, stereoselectivity is rather poor for most of the ct-alkylated products.

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