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Lithium does not attenuate the effects of d-amphetamine in healthy volunteers

✍ Scribed by Peter H Silverstone; Andrew Pukhovsky; Susan Rotzinger

Book ID: 117334616
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 85 KB
Volume: 79
Category: Article
ISSN: 0165-1781
DOI: 10.1016/s0165-1781(98)00037-7

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The phosphoinositide (PI) cycle second messenger system mediates the effect of muscarinic receptor binding. Inositol, which is an essential substrate for phosphoinositide synthesis penetrates the blood-brain barrier poorly, and is vulnerable to depletion. Lithium uncompetitively inhibits inositol-1