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Lithium acetylides as alkynylating reagents for the enantioselective alkynylation of ketones catalyzed by lithium binaphtholate

โœ Scribed by Tanaka, Kana; Kukita, Kenji; Ichibakase, Tomonori; Kotani, Shunsuke; Nakajima, Makoto


Book ID
120511425
Publisher
Royal Society of Chemistry
Year
2011
Tongue
English
Weight
623 KB
Volume
47
Category
Article
ISSN
1359-7345

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Enantioselective alkynylation of ketones
โœ Kana Tanaka; Tomohiro Ueda; Tomonori Ichibakase; Makoto Nakajima ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 171 KB

Chiral lithium 3,3 0 -diphenylbinaphtholate successfully catalyzed the alkynylation of ketone with trimethoxysilylalkyne, affording chiral tertiary propargylic alcohols in high chemical yields and high enantioselectivities. The present reaction could be extended to the alkynylation of acetylpyridine