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Enantioselective alkynylation of carbonyl compounds with trimethoxysilylalkynes catalyzed by lithium binaphtholate

โœ Scribed by Tomohiro Ueda; Kana Tanaka; Tomonori Ichibakase; Yuya Orito; Makoto Nakajima


Book ID
108283383
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
310 KB
Volume
66
Category
Article
ISSN
0040-4020

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Enantioselective alkynylation of ketones
โœ Kana Tanaka; Tomohiro Ueda; Tomonori Ichibakase; Makoto Nakajima ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 171 KB

Chiral lithium 3,3 0 -diphenylbinaphtholate successfully catalyzed the alkynylation of ketone with trimethoxysilylalkyne, affording chiral tertiary propargylic alcohols in high chemical yields and high enantioselectivities. The present reaction could be extended to the alkynylation of acetylpyridine