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Lithium 2,2,6,6-Tetramethylpiperidide-Mediated α- and β-Lithiations of Epoxides: Solvent-Dependent Mechanisms

✍ Scribed by Wiedemann, Sean H.; Ramírez, Antonio; Collum, David B.


Book ID
121745217
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
204 KB
Volume
125
Category
Article
ISSN
0002-7863

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Straightforward synthesis of α,β-epoxysi
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Lithiation-in situ silylation of simple terminal epoxides using lithium 2,2,6,6-tetramethylpiperidide in combination with trimethylsilyl chloride provides a direct and experimentally convenient process for the synthesis of trans-a,b-epoxysilanes.