Straightforward synthesis of α,β-epoxysilanes from terminal epoxides by lithium 2,2,6,6-tetramethylpiperidide-mediated deprotonation-in situ silylation

✍ Scribed by David M. Hodgson; Nigel J. Reynolds; Steven J. Coote

• Book ID: 104252125
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 255 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01893-2

✦ Synopsis

Lithiation-in situ silylation of simple terminal epoxides using lithium 2,2,6,6-tetramethylpiperidide in combination with trimethylsilyl chloride provides a direct and experimentally convenient process for the synthesis of trans-a,b-epoxysilanes.