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Lithiation and Substitution of N′-(ω-Phenylalkyl)-N,N-dimethylureas

✍ Scribed by Smith, Keith; El-Hiti, Gamal; Alshammari, Mohammed

Book ID
121743286
Publisher
Thieme Medical Publishers
Year
2012
Tongue
German
Weight
246 KB
Volume
44
Category
Article
ISSN
0039-7881

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✍ Keith Smith; Gamal A. El-Hiti; Amany S. Hegazy 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 22 KB 👁 2 views

## Abstract Lithiation of ureas (I) and (VI) followed by quenching with various electrophiles, such as aldehydes (II), ketones (IV) and alkyl halides (VII) affords the corresponding 3‐substituted isoindolin‐1‐ones (III), (V), and (VIII), respectively, in good yields.