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Liquid chromatography–tandem mass spectrometry method as the golden standard for therapeutic drug monitoring in renal transplant

✍ Scribed by Aucella, Filippo; Lauriola, Vincenzo; Vecchione, Gennaro; Tiscia, Giovanni Luca; Grandone, Elvira


Book ID
121469641
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
171 KB
Volume
86
Category
Article
ISSN
0731-7085

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## Abstract A simple, reliable and sensitive liquid chromatography tandem mass spectrometry (LC‐MS/MS) protocol was developed and validated for quantification of bisoprolol in human plasma. The sample was pretreated with a simple procedure of protein precipitation and an isotope‐labeled d5‐bisoprol