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Liquid chromatographic determination of the pH-dependent degradation of eseroline — hydrolysis product of physostigmine

✍ Scribed by S.T. Yang; L.O. Wilken; C.R. Clark

Book ID
103910873
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
651 KB
Volume
5
Category
Article
ISSN
0731-7085

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✦ Synopsis

The stability of eseroline, the hydrolysis product of physostigmine under aerobic conditions, was studied by liquid chromatography. A reversed-phase, ion-pair technique was used to separate eseroline from its degradation products. The degradation of eseroline in phosphate buffer solutions of pH 6. 91,7.40,7.98,8.41 and 8.94 appears to follow first-order kinetics; the rate constant increased with an increase in pH. The degradation appears to follow specific base catalysis.

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