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Liquid chromatographic determination of taxol and related derivatives using a new polyfluorinated reversed-phase column

✍ Scribed by Hassan Y. Aboul-Enein; Vince Serignese

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
314 KB
Volume
319
Category
Article
ISSN
0003-2670

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✦ Synopsis

Taxol (paclitaxel) and 5 of its commonly known derivatives (cephalomannine, 7-epi-lo-deacetyltaxol, lo-deacetyltaxol, lo-deacetylbaccatin III, baccatin III) were separated by a liquid chromatographic method using a new commercially available polyfluorinated reversed-phase column, known as Fluofix @. The assay achieved good resolution with the exception of cephalomannine and 7-epi-lo-deacetyltaxol. An injectable formulation of taxol was validated using this method. The results were consistent and the procedure could be used for quality control or purity determinations of taxol in bulk and pharmaceutical dosage forms.

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## Abstract The use of 3‐methylimidazolium cation‐based ionic liquids (ILs) was evaluated as mobile phase additives for separation of antiretroviral drugs on a monolithic column by RP‐HPLC. Separation of eight commonly used antiretroviral drugs was achieved on a Chromolith Flash, RP‐18e column (25Γ—