𝔖 Bobbio Scriptorium
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Liposome–collagen gel matrix: A novel sustained drug delivery system

✍ Scribed by Alan L. Weiner; Sharon S. Carpenter-Green; Ellen C. Soehngen; Robert P. Lenk; Mircea C. Popescu

Book ID
102916305
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
553 KB
Volume
74
Category
Article
ISSN
0022-3549

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✦ Synopsis

l i This report describes the properties of a novel sustainedrelease drug delivery system comprising liposomes sequestered in a collagen gel. Two peptide hormones, insulin and growth hormone encapsulated in vesicles sequestered within the matrix, are slowly released into the circulation from either an intramuscular or subcutaneous injection site. A maximum 3-5-d release for insulin or a 14-d growth hormone release was observed. Enhanced sequestration of liposomes with the collagen can be achieved by modifying the liposome surface with fibronectin. The liposome gel delivery system appears to offer several advantages over other liposome formulations or gel formulations constructed only with free drug.

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## Abstract **Summary:** A novel drug delivery system, bullfrog skin collagen film, was employed to release bovine serum albumin (BSA). The biophysical properties of bullfrog skin collagen film used were evaluated by thermal denaturation temperature and percentage water loss. The film obtained exhi