Sustained Release of BSA from a Novel Drug Delivery Matrix – Bullfrog Skin Collagen Film
✍ Scribed by He Li; Diqiang Wang; Songjun Li; Bailing Liu; Lizhen Gao
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 210 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1616-5187
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Summary: A novel drug delivery system, bullfrog skin collagen film, was employed to release bovine serum albumin (BSA). The biophysical properties of bullfrog skin collagen film used were evaluated by thermal denaturation temperature and percentage water loss. The film obtained exhibited good stability and can be taken as a good candidate for drug delivery matrix. Compared with conventional collagen from molecular weight and amino acid composition, bullfrog skin collagen showed significant differences. For safety considerations, bullfrog skin collagen has great advantages. The release kinetics of BSA from bullfrog skin collagen film was measured in vitro. The results indicated bullfrog skin collagen film could be used for sustained release of BSA. Thus, bullfrog skin collagen film can be taken as a novel drug delivery system.
Morphology of frog collagen film with drug loaded after release.
imageMorphology of frog collagen film with drug loaded after release.