Liposome-mediated adenomatous polyposis coll (APC) gene transfer in familial adenomatous polyposis (FAP)
β Scribed by Lee, Jack; Hargest, Rachel; Wasan, Harpreet; Phillips, Robin R.
- Book ID
- 124140877
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 185 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0016-5085
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π SIMILAR VOLUMES
Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra-colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline D N A of 81 unrelated FAP patients and evalua
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm