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Liposome-Encapsulated Hemoglobin Ameliorates Tumor Hypoxia and Enhances Radiation Therapy to Suppress Tumor Growth in Mice

✍ Scribed by Chieko Murayama; Akira T. Kawaguchi; Kenji Ishikawa; Akemi Kamijo; Nobusuke Kato; Yukio Ohizumi; Sotaro Sadahiro; Munetaka Haida

Book ID
115311183
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
482 KB
Volume
36
Category
Article
ISSN
0160-564X

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Liposome-Encapsulated Hemoglobin Amelior
Liposome-Encapsulated Hemoglobin Ameliorates Tumor Hypoxia and Enhances Radiation Therapy to Suppress Tumor Growth in Mice
✍ Chieko Murayama; Akira T. Kawaguchi; Kenji Ishikawa; Akemi Kamijo; Nobusuke Kato 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 482 KB

## Abstract We hypothesize that liposome‐encapsulated hemoglobin with high O~2~ affinity (P~50~0~2~ = 12 mm Hg, h‐LEH) may increase O~2~ delivery to hypoxic tumors and enhance radiation therapy synergistically to suppress tumor growth. First, h‐LEH (5, 10, and 20 mL/kg) was intravenously infused 30